We are working with a global pharmaceutical CRO/CMO in Manchester who require Development Chemists to optimise synthetic procedures and design processes for the production of pharmaceutical intermediates on a kg-ton scale. This role is lab based and requires a good understanding of practical synthetic organic chemistry and an enthusiasm for lab work.
What you’ll do
You will be working on chemical processes, optimising reaction conditions and work-up procedures in pre-defined synthetic routes to improve product purity & yield, process robustness, process understanding and process safety. You will have the opportunity to work on a variety of organic reactions, for example protections/deprotections, reductions/oxidations, alkylations, nucleophilic additions, hydrogenations, cyclisations, metal catalysed couplings, crystallisations and many more. You will work closely with Project Chemists and Team Leaders to design experiments with clear aims, ultimately creating elegant and efficient processes to support manufacturing at kg-ton scale. Development reactions typically use 1-1000 g of starting material and are executed with a strong attention to detail, obtaining as much information as possible from each experiment. You will gain an understanding of requirements for scale-up and your input, observations and suggestions will be vital to the progression of process design.
You will maintain accurate records and work closely with colleagues; effective and frequent communication across the site will be required. You will interact with Analytical and QC personnel regularly and plan your work to meet project goals within required timeframes.
You will have graduated with a Masters or PhD in Chemistry and carried out research in a synthesis-based group. You will have a record of accomplishment in practical organic chemistry in either industry or academia and, most importantly, an enthusiasm for process development and scale-up.
We look forward to receiving your application!
On this occasion, LiCa Scientific is acting as an employment agency.
Job Types: Full-time, Permanent